As I've said before, I'm not exactly a big graphic novel/comics reader, but only because I find the medium to be intimidating and inaccessible. I really enjoyed reading Alison Bechdel's graphic memoirs, and got a good response from readers, so I decided to give Persepolis a try, which is probably a much better-known graphic novel because it was adapted into an animated film in 2007.
I'm probably giving myself too much credit for reading two very critically-acclaimed graphic memoirs by women authors -- I still can't call myself a comic book fan or reader. However, I really enjoyed Persepolis and along with Alison Bechdel, it is has served as a good segue into the genre. A lot of folks don't like reading graphic novels or comics because the flow of panels can be confusing, but I read a lot of Archies as a kid, so that's never been a problem for me. I still found Persepolis to be an easy, quick read, and the narrative/panel structure felt very natural. I particularly love Satrapi's stylization, which results in very graphic, very minimalist panels, and very unlike a lot of comic book artwork you might have seen.